アルツハイマー病の原因がわかったー② [健康・医療お役立ち情報]
①からの続き
「我々の今回の実験データが示しているように、タウ病理が内嗅皮質内で発生し、そこから転移が広まっていくとすれば、最も効果的アプローチは、がんの治療法と同じように、タウが他の部位に転移する前に、早期発見、早期治療でアルツハイマー病を治療することかもしれない。」と研究チームの１人であるコロンビア大学医療センターのスコット博士は話している。
「この初期の段階においてこそ、アルツハイマー病の治療は効果があるのです。今回の発見は臨床学的に見て将来大いに期待できるものです。」とスコット博士は話している。
今回の発見は、パーキンソン病のようなその他の神経性疾患がどのように進行していくのかについての新しい解決の糸口も与えることになるとニューヨーク・タイムズは報じている。
米アルツハイマー病協会の医科学部長のウイリアム・シース博士はCBS Newsに次のように語った。
「今回の発見はまだ初期的段階の調査に過ぎません。調査結果の全容解明には今後さらに５年はかかるでしょう。」
「今回の研究者たちの推測が正しくて、タウの細胞への転移の動きを食い止めることが出来る方法が見つかれば、それは有効な治療方法となるでしょう。でも、人間の病気治療に利用できるような有効な医薬品を手に入れるまでには、越えなければならないステップが幾つもあります」とシース博士は話している。
アメリカのアルツハイマー病患者は推定で540万人いるとされている。疾病対策予防センターの最近の調査によると、アルツハイマー病は死亡率が６位となっている病気で、この１年間で８万３千人が亡くなっているという。」
★アルツハイマー病関連のブログはこちらです
●アルツハイマー病はAngry Birdsで阻止ー後編
●アルツハイマー病はAngry Birdsで阻止ー前編
●バーチャル・ゲームマシーンで高齢者も心身ともにすっきりー後編
●バーチャル・ゲームマシーンで高齢者も心身ともにすっきりー前編
●禁煙用のニコチンパッチが記憶力低下予防に効果ありー後編
●禁煙用のニコチンパッチが記憶力低下予防に効果ありー前編
●アルツハイマーの予防ー魚を食べるのが一番
Alzheimer's disease "jumps" across brain cells to spread
(CBS) Alzheimer's disease spreads through the brain by jumping from one cell to another, according to a new study.
The study found that tau protein, which indicates the fibrous tangles found in the brains of Alzheimer's patients, spreads along the brain's neurons from one region to the other - resulting in severe dementia. The new clues to the neurodegenerative brain disorder might help scientists find a way to stop the disease from getting worse.
For the study - published in the Feb. 1 issue of PLoS One - researchers genetically modified mice to have a human gene for the abnormal tau protein in an area of the brain's temporal lobe where tau is thought to begin to accumulate. The researchers analyzed the mice brains over a 22-month period to map the protein's spread and found that as mice aged, the tau spread to different regions of their brains across synapses - the junctions neurons use to communicate with each other.
"This pattern very much follows the staging that we see at the earliest stages of human Alzheimer's disease," senior study author Dr. Karen E. Duff, professor of pathology at the Columbia University Medical Center in New York City, said in a written statement.
Duff told the New York Times that the mouse study answers many questions, since scientists had long thought the disease spread through some mechanism from one brain region to the other, but human autopsies and brain scan studies have been inconclusive. Duff told the paper that's because looking at brains of people who died with Alzheimer's is like "looking at a wrecked car and trying to find out the accident's cause."
The study authors now hope their new findings can be used to improve treatments.
"If, as our data suggest, tau pathology starts in the entorhinal cortex and emanates from there, the most effective approach may be to treat Alzheimer's the way we treat cancer - through early detection and treatment, before it has a chance to spread," study co-author Dr. Scott A. Small, professor of neurology at the Columbia University Medical Center, said in the statement. "It is during this early stage that the disease will be most amenable to treatment. That is the exciting clinical promise down the road."
The findings may also provide new clues on how other neurodegenerative disorders, like Parkinson's spread, the New York Times reported.
Dr. William Thies, chief medical & science officer at the Alzheimer's Association told CBS News that the findings are still early science, and it could take up to five years to really learn what the study's implications are.
"If the speculation of these investigators is correct and you can find a way to interrupt the movement of tau from one neuron to another, that might be a useful therapeutic pathway," Thies told CBS News. "But there are many steps that have to come before you're actually going to get to a useful product that could be used to treat human disease."
An estimated 5.4 million Americans live with Alzheimer's disease. Alzheimer's disease is the sixth leading cause of death in the U.S., according to the CDC's latest report, taking more than 83,000 lives this past year.
(CBS News 2012/02/02)
「我々の今回の実験データが示しているように、タウ病理が内嗅皮質内で発生し、そこから転移が広まっていくとすれば、最も効果的アプローチは、がんの治療法と同じように、タウが他の部位に転移する前に、早期発見、早期治療でアルツハイマー病を治療することかもしれない。」と研究チームの１人であるコロンビア大学医療センターのスコット博士は話している。
「この初期の段階においてこそ、アルツハイマー病の治療は効果があるのです。今回の発見は臨床学的に見て将来大いに期待できるものです。」とスコット博士は話している。
今回の発見は、パーキンソン病のようなその他の神経性疾患がどのように進行していくのかについての新しい解決の糸口も与えることになるとニューヨーク・タイムズは報じている。
米アルツハイマー病協会の医科学部長のウイリアム・シース博士はCBS Newsに次のように語った。
「今回の発見はまだ初期的段階の調査に過ぎません。調査結果の全容解明には今後さらに５年はかかるでしょう。」
「今回の研究者たちの推測が正しくて、タウの細胞への転移の動きを食い止めることが出来る方法が見つかれば、それは有効な治療方法となるでしょう。でも、人間の病気治療に利用できるような有効な医薬品を手に入れるまでには、越えなければならないステップが幾つもあります」とシース博士は話している。
アメリカのアルツハイマー病患者は推定で540万人いるとされている。疾病対策予防センターの最近の調査によると、アルツハイマー病は死亡率が６位となっている病気で、この１年間で８万３千人が亡くなっているという。」
★アルツハイマー病関連のブログはこちらです
●アルツハイマー病はAngry Birdsで阻止ー後編
●アルツハイマー病はAngry Birdsで阻止ー前編
●バーチャル・ゲームマシーンで高齢者も心身ともにすっきりー後編
●バーチャル・ゲームマシーンで高齢者も心身ともにすっきりー前編
●禁煙用のニコチンパッチが記憶力低下予防に効果ありー後編
●禁煙用のニコチンパッチが記憶力低下予防に効果ありー前編
●アルツハイマーの予防ー魚を食べるのが一番
Alzheimer's disease "jumps" across brain cells to spread
(CBS) Alzheimer's disease spreads through the brain by jumping from one cell to another, according to a new study.
The study found that tau protein, which indicates the fibrous tangles found in the brains of Alzheimer's patients, spreads along the brain's neurons from one region to the other - resulting in severe dementia. The new clues to the neurodegenerative brain disorder might help scientists find a way to stop the disease from getting worse.
For the study - published in the Feb. 1 issue of PLoS One - researchers genetically modified mice to have a human gene for the abnormal tau protein in an area of the brain's temporal lobe where tau is thought to begin to accumulate. The researchers analyzed the mice brains over a 22-month period to map the protein's spread and found that as mice aged, the tau spread to different regions of their brains across synapses - the junctions neurons use to communicate with each other.
"This pattern very much follows the staging that we see at the earliest stages of human Alzheimer's disease," senior study author Dr. Karen E. Duff, professor of pathology at the Columbia University Medical Center in New York City, said in a written statement.
Duff told the New York Times that the mouse study answers many questions, since scientists had long thought the disease spread through some mechanism from one brain region to the other, but human autopsies and brain scan studies have been inconclusive. Duff told the paper that's because looking at brains of people who died with Alzheimer's is like "looking at a wrecked car and trying to find out the accident's cause."
The study authors now hope their new findings can be used to improve treatments.
"If, as our data suggest, tau pathology starts in the entorhinal cortex and emanates from there, the most effective approach may be to treat Alzheimer's the way we treat cancer - through early detection and treatment, before it has a chance to spread," study co-author Dr. Scott A. Small, professor of neurology at the Columbia University Medical Center, said in the statement. "It is during this early stage that the disease will be most amenable to treatment. That is the exciting clinical promise down the road."
The findings may also provide new clues on how other neurodegenerative disorders, like Parkinson's spread, the New York Times reported.
Dr. William Thies, chief medical & science officer at the Alzheimer's Association told CBS News that the findings are still early science, and it could take up to five years to really learn what the study's implications are.
"If the speculation of these investigators is correct and you can find a way to interrupt the movement of tau from one neuron to another, that might be a useful therapeutic pathway," Thies told CBS News. "But there are many steps that have to come before you're actually going to get to a useful product that could be used to treat human disease."
An estimated 5.4 million Americans live with Alzheimer's disease. Alzheimer's disease is the sixth leading cause of death in the U.S., according to the CDC's latest report, taking more than 83,000 lives this past year.
(CBS News 2012/02/02)
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